Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.6
USERS' SCORE
Good
Based on 5 Reviews
8.1
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Calcium (elemental) (from 2,775 mg complex of Calcium Carbonate, Calcium Citrate, Calcium Ascorbate)
1 g (1,000 mg)
77%
Magnesium (elemental) (from 928 mg complex of Magnesium Oxide, Magnesium Citrate, Magnesium Ascorbate)
500 mg
119%
Top Medical Research Studies
8
Magnesium scaffold shows promising results
We investigated the clinical safety and performance of a new magnesium scaffold known as DREAMS 3G. This innovative treatment aims to match the effectiveness of drug-eluting stents in coronary interventions.
Over one year, a total of 116 patients were monitored, showing promising results with minimal lumen loss and no adverse events like cardiac death or major thrombosis. Despite a few revascularization interventions, the scaffold appears to be a viable alternative.
Overall, our findings support its potential use in heart treatments.
Over one year, a total of 116 patients were monitored, showing promising results with minimal lumen loss and no adverse events like cardiac death or major thrombosis. Despite a few revascularization interventions, the scaffold appears to be a viable alternative.
Overall, our findings support its potential use in heart treatments.
9
We investigated the effects of magnesium oxide nanoparticles, created using fruit extract, on blood clotting and oxidative stress. Our experiments showed that these nanoparticles significantly extended clotting time, indicating an anticoagulant effect. They also effectively reduced damage to red blood cells and various tissues in laboratory tests, helping to restore their function. Importantly, we found these nanoparticles non-toxic, suggesting they could be a promising treatment option for oxidative stress-related conditions without adverse side effects. However, further research is needed to fully understand their potential in clinical applications.
8
We explored the impact of different calcium infusions on clotting risks in neonates undergoing cardiac surgery. Our study involved analyzing data from 135 babies who received either calcium chloride or calcium gluconate during their treatment.
The findings highlighted a significant concern: when using calcium chloride, the incidence of thrombotic events was notably higher compared to those treated with calcium gluconate. Specifically, the odds of experiencing a blood clot were over three times greater in patients given calcium chloride.
With an overall thrombus occurrence of 9.9%, we observed that only 4.6% of the group receiving calcium gluconate developed such complications compared to 15% in the calcium chloride group. The evidence suggests that switching from calcium chloride to calcium gluconate could potentially reduce the risk of harmful blood clots in these vulnerable patients.
The findings highlighted a significant concern: when using calcium chloride, the incidence of thrombotic events was notably higher compared to those treated with calcium gluconate. Specifically, the odds of experiencing a blood clot were over three times greater in patients given calcium chloride.
With an overall thrombus occurrence of 9.9%, we observed that only 4.6% of the group receiving calcium gluconate developed such complications compared to 15% in the calcium chloride group. The evidence suggests that switching from calcium chloride to calcium gluconate could potentially reduce the risk of harmful blood clots in these vulnerable patients.
Most Useful Reviews
9
Blood pressure stabilised
2 people found this helpful
A great mix! My wife had severe blood pressure issues until I realised our previous magnesium-calcium supplement had changed, removing calcium. After switching to Now supplements, her blood pressure returned to normal. We found iHerb offered this at a better price, so weāll continue buying from them.
4
Lowered blood pressure
1 people found this helpful
Useful for bone health and lowering blood pressure! My slightly high blood pressure improved when I combined this supplement with my medication. My hair also grew faster and stronger. The tablets may be large for some, so I recommend taking with vitamin D3 and K2 for better absorption.
7.5
Reduced diabetes symptoms
3 people found this helpful
Essential for diabetes! I purchased it for my mother with diabetes and she took it nightly for 3 weeks. Her fasting blood sugar level gradually decreased to 102, which is normal. I've repurchased it for her to continue taking.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.6
- All Researches
9
We explored the role of calcium in promoting blood coagulation using a new zeolite-embedded regenerated cellulose aerogel (Z-RCA). This innovative hemostatic agent was designed to minimize common issues seen with previous zeolite-based products, like heat-induced tissue damage and unwanted blood clotting elsewhere in the body.
Our results showed that this aerogel effectively absorbed blood while releasing calcium ions, which play a crucial role in the blood clotting process. By combining the properties of zeolite and the calcium-releasing ability of the aerogel, we found that Z-RCA not only facilitated quicker blood clotting but did so safely, with less risk of adverse effects.
In animal trials, we observed that Z-RCA stopped bleeding faster than existing options like Quikclot and notably reduced blood loss by over 62%. This combination of effectiveness and safety makes Z-RCA a promising solution for achieving efficient hemostasis during emergencies.
Our results showed that this aerogel effectively absorbed blood while releasing calcium ions, which play a crucial role in the blood clotting process. By combining the properties of zeolite and the calcium-releasing ability of the aerogel, we found that Z-RCA not only facilitated quicker blood clotting but did so safely, with less risk of adverse effects.
In animal trials, we observed that Z-RCA stopped bleeding faster than existing options like Quikclot and notably reduced blood loss by over 62%. This combination of effectiveness and safety makes Z-RCA a promising solution for achieving efficient hemostasis during emergencies.
9
We investigated the effects of magnesium oxide nanoparticles, created using fruit extract, on blood clotting and oxidative stress. Our experiments showed that these nanoparticles significantly extended clotting time, indicating an anticoagulant effect. They also effectively reduced damage to red blood cells and various tissues in laboratory tests, helping to restore their function. Importantly, we found these nanoparticles non-toxic, suggesting they could be a promising treatment option for oxidative stress-related conditions without adverse side effects. However, further research is needed to fully understand their potential in clinical applications.
8
We explored the impact of different calcium infusions on clotting risks in neonates undergoing cardiac surgery. Our study involved analyzing data from 135 babies who received either calcium chloride or calcium gluconate during their treatment.
The findings highlighted a significant concern: when using calcium chloride, the incidence of thrombotic events was notably higher compared to those treated with calcium gluconate. Specifically, the odds of experiencing a blood clot were over three times greater in patients given calcium chloride.
With an overall thrombus occurrence of 9.9%, we observed that only 4.6% of the group receiving calcium gluconate developed such complications compared to 15% in the calcium chloride group. The evidence suggests that switching from calcium chloride to calcium gluconate could potentially reduce the risk of harmful blood clots in these vulnerable patients.
The findings highlighted a significant concern: when using calcium chloride, the incidence of thrombotic events was notably higher compared to those treated with calcium gluconate. Specifically, the odds of experiencing a blood clot were over three times greater in patients given calcium chloride.
With an overall thrombus occurrence of 9.9%, we observed that only 4.6% of the group receiving calcium gluconate developed such complications compared to 15% in the calcium chloride group. The evidence suggests that switching from calcium chloride to calcium gluconate could potentially reduce the risk of harmful blood clots in these vulnerable patients.
8
We explored whether magnesium intake could influence the risk of retinal vein occlusion (RVO), a leading cause of vision loss. Our analysis involved over 16,000 participants from a national health survey.
We discovered that sufficient magnesium intake was linked to a significant 64% reduced risk of RVO.
This finding was especially relevant for adults under 60, those with hypertension, and individuals without glaucoma. Further studies are needed to confirm magnesium's preventive benefits for RVO.
We discovered that sufficient magnesium intake was linked to a significant 64% reduced risk of RVO.
This finding was especially relevant for adults under 60, those with hypertension, and individuals without glaucoma. Further studies are needed to confirm magnesium's preventive benefits for RVO.
8
Effective clay-based hemostatic sponge
We examined a new sponge made from clay and collagen to control severe bleeding. Integrating palygorskite clay with collagen using gallic acid created a sponge that resists particle shedding and provides strong adhesion.
In our tests, this sponge demonstrated impressive results, reducing blood loss to 632 mg and achieving hemostasis in just 151 seconds, outperforming traditional gauze and even a well-known product called QuikClot.
With added antibacterial and antioxidant properties, this sponge could significantly enhance emergency bleeding management.
In our tests, this sponge demonstrated impressive results, reducing blood loss to 632 mg and achieving hemostasis in just 151 seconds, outperforming traditional gauze and even a well-known product called QuikClot.
With added antibacterial and antioxidant properties, this sponge could significantly enhance emergency bleeding management.
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Blood pressure stabilised
2 people found this helpful
A great mix! My wife had severe blood pressure issues until I realised our previous magnesium-calcium supplement had changed, removing calcium. After switching to Now supplements, her blood pressure returned to normal. We found iHerb offered this at a better price, so weāll continue buying from them.
4
Lowered blood pressure
1 people found this helpful
Useful for bone health and lowering blood pressure! My slightly high blood pressure improved when I combined this supplement with my medication. My hair also grew faster and stronger. The tablets may be large for some, so I recommend taking with vitamin D3 and K2 for better absorption.
7.5
Reduced diabetes symptoms
3 people found this helpful
Essential for diabetes! I purchased it for my mother with diabetes and she took it nightly for 3 weeks. Her fasting blood sugar level gradually decreased to 102, which is normal. I've repurchased it for her to continue taking.
7.5
Improved wellbeing
1 people found this helpful
I bought this for my mother with diabetes. She feels better after taking it, so Iāll keep providing it. Calcium can also help lower blood pressure, and since it's not a pressed capsule, thereās no waste.
7.5
Long-term benefit
1 people found this helpful
Very effective! Despite the pills being large, I manage to take them. The quality ingredients are beneficial for lowering blood pressure. I ensure my child takes one before bed to prevent any issues, making it a supplement I intend to continue using long-term.
Frequently Asked Questions
9
Blood pressure stabilised
2 people found this helpful
A great mix! My wife had severe blood pressure issues until I realised our previous magnesium-calcium supplement had changed, removing calcium. After switching to Now supplements, her blood pressure returned to normal. We found iHerb offered this at a better price, so weāll continue buying from them.
4
Lowered blood pressure
1 people found this helpful
Useful for bone health and lowering blood pressure! My slightly high blood pressure improved when I combined this supplement with my medication. My hair also grew faster and stronger. The tablets may be large for some, so I recommend taking with vitamin D3 and K2 for better absorption.
7.5
Reduced diabetes symptoms
3 people found this helpful
Essential for diabetes! I purchased it for my mother with diabetes and she took it nightly for 3 weeks. Her fasting blood sugar level gradually decreased to 102, which is normal. I've repurchased it for her to continue taking.
7.5
Improved wellbeing
1 people found this helpful
I bought this for my mother with diabetes. She feels better after taking it, so Iāll keep providing it. Calcium can also help lower blood pressure, and since it's not a pressed capsule, thereās no waste.
9
We explored the role of calcium in promoting blood coagulation using a new zeolite-embedded regenerated cellulose aerogel (Z-RCA). This innovative hemostatic agent was designed to minimize common issues seen with previous zeolite-based products, like heat-induced tissue damage and unwanted blood clotting elsewhere in the body.
Our results showed that this aerogel effectively absorbed blood while releasing calcium ions, which play a crucial role in the blood clotting process. By combining the properties of zeolite and the calcium-releasing ability of the aerogel, we found that Z-RCA not only facilitated quicker blood clotting but did so safely, with less risk of adverse effects.
In animal trials, we observed that Z-RCA stopped bleeding faster than existing options like Quikclot and notably reduced blood loss by over 62%. This combination of effectiveness and safety makes Z-RCA a promising solution for achieving efficient hemostasis during emergencies.
Our results showed that this aerogel effectively absorbed blood while releasing calcium ions, which play a crucial role in the blood clotting process. By combining the properties of zeolite and the calcium-releasing ability of the aerogel, we found that Z-RCA not only facilitated quicker blood clotting but did so safely, with less risk of adverse effects.
In animal trials, we observed that Z-RCA stopped bleeding faster than existing options like Quikclot and notably reduced blood loss by over 62%. This combination of effectiveness and safety makes Z-RCA a promising solution for achieving efficient hemostasis during emergencies.
7
We looked into how magnesium levels impact blood clotting during sepsis. In our study of ICU patients, we found that those with low magnesium (hypomagnesemia) showed a higher likelihood of having activated coagulation and suppressed fibrinolysis.
Notably, hypomagnesemia was linked to coagulopathy, specifically disseminated intravascular coagulation (DIC). This suggests that boosting magnesium levels could be a promising way to address blood clotting issues in septic patients.
Notably, hypomagnesemia was linked to coagulopathy, specifically disseminated intravascular coagulation (DIC). This suggests that boosting magnesium levels could be a promising way to address blood clotting issues in septic patients.
References
- Jin Z, Chen L, Liu X, Xia R, Li W, et al. Zeolite firmly anchored regenerated cellulose aerogel for efficient and biosafe hemostasis. Int J Biol Macromol. 2025;304:140743. 10.1016/j.ijbiomac.2025.140743
- Tran VA, Griffin EM, Elliott JD, Scholl RL, Hill RB, et al. Thrombotic Complications Associated With Right Atrial Lines in Neonates and Infants Undergoing Cardiac Surgery. Is Calcium Chloride a Culprit?. J Cardiothorac Vasc Anesth. 2025. 10.1053/j.jvca.2025.01.008
- Kim J, Kim M, Lee CS, Choi EY. Sufficient Magnesium Intake Reduces Retinal Vein Occlusion Risk: National Health and Nutrition Examination Survey Analysis. Nutrients. 2025;17. 10.3390/nu17071285
- Guo X, Zeng X, He Y, Zhang X, Shi W, et al. An Antibacterial, Antioxidant Adherent Sponge Constructed for Control of Arterial Bleeding Via Gallic Acid-Mediated Robust Assembly of Fibrous Clay in Collagen. ACS Appl Mater Interfaces. 2025;17:16489. 10.1021/acsami.4c19209
- MĆ¼ller M, Ludwig L, Englert H, Riedl KA, MĆ¼ller MC, et al. A novel stent flow chamber system demonstrates reduced thrombogenicity of bioresorbable magnesium scaffolds. Sci Rep. 2024;14:26691. 10.1038/s41598-024-77266-0
- Zhang J, Chen Z, Rao L, He Y. Coronary bioresorbable metallic stents: Advancements and future perspectives. J Cardiol. 2025;85:69. 10.1016/j.jjcc.2024.08.003
- WÅodarczak A, Rola P, WÅodarczak S, Szudrowicz M, Giniewicz K, et al. Two-Year Outcomes for Patients with Non-ST-Elevation Acute Coronary Syndrome Treated with Magmaris and Absorb Bioresorbable Scaffolds in Large-Vessel Lesions. J Pers Med. 2024;14. 10.3390/jpm14050540
- Galli S, Troiano S, Palloshi A, Rapetto C, Pisano F, et al. Comparison of acute versus stable coronary syndrome in patients treated with the Magmaris scaffold: Two-year results from the Magmaris Multicenter Italian Registry. Cardiovasc Revasc Med. 2023;57:53. 10.1016/j.carrev.2023.06.022
- WÅodarczak A, Rola P, Barycki M, Furtan Å, Åanocha M, et al. Mid-term safety and efficacy of magnesium bioresorbable vascular scaffolds - magmaris in diabetic population. 2-Years outcome in acute coronary syndrome cohort. Diab Vasc Dis Res. 2023;20:14791641231188705. 10.1177/14791641231188705
- Gotru SK, Mammadova-Bach E, Sogkas G, Schuhmann MK, Schmitt K, et al. MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice. Arterioscler Thromb Vasc Biol. 2023;43:1494. 10.1161/ATVBAHA.122.318115
- Haude M, Wlodarczak A, van der Schaaf RJ, Torzewski J, Ferdinande B, et al. A new resorbable magnesium scaffold for de novo coronary lesions (DREAMS 3): one-year results of the BIOMAG-I first-in-human study. EuroIntervention. 2023;19:e414. 10.4244/EIJ-D-23-00326
- Wlodarczak A, Montorsi P, Torzewski J, Bennett J, Starmer G, et al. One- and two-year clinical outcomes of treatment with resorbable magnesium scaffolds for coronary artery disease: the prospective, international, multicentre BIOSOLVE-IV registry. EuroIntervention. 2023;19:232. 10.4244/EIJ-D-22-01069
- Haude M, Wlodarczak A, van der Schaaf RJ, Torzewski J, Ferdinande B, et al. Safety and performance of the third-generation drug-eluting resorbable coronary magnesium scaffold system in the treatment of subjects with de novo coronary artery lesions: 6-month results of the prospective, multicenter BIOMAG-I first-in-human study. EClinicalMedicine. 2023;59:101940. 10.1016/j.eclinm.2023.101940
- Pompei G, Campo G, Ruggiero R, Maffeo D, Sgura F, et al. Long-term outcomes of patients treated with sirolimus-eluting resorbable magnesium scaffolds: Insights from the SHERPA-MAGIC study. Int J Cardiol. 2023;383:1. 10.1016/j.ijcard.2023.04.029
- Fedele G, Castiglioni S, Maier JAM, Locatelli L. The Effects of Sirolimus and Magnesium on Primary Human Coronary Endothelial Cells: An In Vitro Study. Int J Mol Sci. 2023;24. 10.3390/ijms24032930
- Tonai K, Katayama S, Koyama K, Sata N, Tomioka Y, et al. Association between hypomagnesemia and coagulopathy in sepsis: a retrospective observational study. BMC Anesthesiol. 2022;22:359. 10.1186/s12871-022-01903-2
- Seguchi M, Aytekin A, Lenz T, Nicol P, Alvarez-Covarrubias HA, et al. Challenges of the newer generation of resorbable magnesium scaffolds: Lessons from failure mechanisms of the past generation. J Cardiol. 2023;81:179. 10.1016/j.jjcc.2022.09.003
- Venkatappa MM, Udagani C, Hanumegowda SM, Pramod SN, Venkataramaiah S, et al. Effect of Biofunctional Green Synthesized MgO-Nanoparticles on Oxidative-Stress-Induced Tissue Damage and Thrombosis. Molecules. 2022;27. 10.3390/molecules27165162
